Studies of intercellular invasion in vitro using rabbit peritoneal neutrophil granulocytes (PMNS). I. Role of contact inhibition of locomotion

STUDIES ON INTERCELLULAR INVASION IN VITRO USING RABBIT PERITONEAL NEUTROPHIL GRANULOCYTES (PMNS) I. Role of Contact Inhibition of Locomotion

Intercellular invasion is the active migration of cells of one type into the interiors of tissues composed of cells of dissimilar cell types. Contact paralysis of locomotion is the cessation of forward extension of the pseudopods of a cell as a result of its collision with another cell. One hypothesis to account for intercellular invasion proposes that a necessary condition for a cell type to b...

Studies on intercellular invasion in vitro using rabbit peritoneal neutrophil granulocytes. II. Adhesive interaction between cells.

A possible mechanism for intercellular invasion is that the strength of adhesion between host and invading cells is greater than the average of the strengths of homotypic adhesions. This hypothesis has been examined by a study of the kinetics of aggregation of dispersed populations of an invasive cell type (the rabbit peritoneal neutrophil granulocyte) and a host cell type (the chick embryo hea...

Neutrophil granulocytes: adhesion and locomotion on collagen substrata and in collagen matrices.

Neutrophil granulocytes (PMNs) adhere poorly to and are unable to locomote on collagen-coated glass; they are able to attach to and invade three-dimensional matrices of collagen fibres. Invasion is largely independent of adhesion to the fibres, does not occur by proteolysis of the gel, and is not affected by the presence of fibronectin or chondroitin sulphate. Invasion is reduced by increasing ...

Inhibition of Eimeria acervulina Sporozoite Invasion by Rabbit and Chicken Antisera Using ISI Assay

Augmentation by Platelets of Granulocyte Aggregation in Response to Chemotaxins: Studies Utilizing an Improved Cell Preparation Technique

Considerable evidence exists to suggest roles for both platelets and granulocytes (PMNs) in pulmonary injury in shock. While believing that the major contributions of the two cell types are sequential. in vitro observations suggested that direct interactions between granulocytes and platelets might also amplify tissue damage. Using isotonic Percoll density gradients to isolate PMNs. we therefor...